Objective: To evaluate the results of corneal transplantation for pseudophakic bullous keratopathy; to analyze the possible variables that could affect the final result. Material and method: We performed a case series study. We included 19 patients (20 eyes) who were treated with penetrating keratoplasty for bullous keratopathy. Surgery was performed with same technique and same surgeon (JEVG) in a 4-year period (January 2000 . June 2004). Results: The average age at the diagnosis of bullous keratopathy was 62 years; the mean follow-up period was 44 months; the average interval between cataract extraction and the diagnosis of bullous keratopathy was 24 months; the average interval between the diagnosis of bullous keratopathy and penetrating keratoplasty was 20 months. The corneal graft remained clear in 70% of cases. The post surgical visual acuities were 20/40 or better in 10% of cases, from 20/50 to 20/100 in 55%, and 20/200 or worse in 25%. Forty percent of cases had cystoid macular edema, with a visual acuity of 20/50 or worse. Conclusions: Although penetrating keratoplasty is nowadays the only solution for pseudophakic bullous keratopathy its results are not the expected. Mainly, for the diversity of factors that might influence the final result.