Prognosis factors for keratoconjunctivitis sicca in patients with Sjögren syndrome Factores pronósticos de gravedad de la queratoconjuntivitis sicca en pacientes con síndrome de Sjögren
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Objective: Sjögren syndrome (SS) is a multisystemic disease characterized by keratoconjunctivitis sicca (KCS). There is no correlation between dry eye severity and the clinical course of the disease. It is relevant to know if there are factors that contribute to the severity to the disease. Method: A total of 80 patients with SS, follow up at 3 months with complete eye examinations and laboratory test were included. We classified KCS as severe and non severe. During this research we compared clinical and demographic factors as well as laboratory test to evaluate which ones could be a prognosis factor for severe dry eye. Results: We studied 80 patients (160 eyes) of which 53 (66.25%) were classified as severe KCS. Anti-Ro antibodies were present in 26 (59.09%) of cases with severe KCS and in 7 (36.84%) of non severe cases. Conclusion: Demographic factors as well as clinical and laboratory characteristics did not show significant differences between severe and non severe KCS. Anti-Ro antibodies were the only exception, with a slight tendency to be present in the severe KCS group. © 2010 Sociedad Mexicana de Oftalmología.