Prevalence of ophthalmic manifestations in patients with systemic lupus erythematosus Prevalencia de manifestaciones oftalmológicas en pacientes con lupus eritematoso sistémico Academic Article in Scopus uri icon


  • Objective: To describe the ophthalmic manifestations of systemic lupus erythematosus (SLE) in Mexican patients. Materials and methods: Descriptive study of patients with SLE seen at the Immunology and Uveitis Service at Instituto de Oftalmología y Ciencias Visuales TEC Salud, del Sistema Tecnológico de Monterrey. Data were obtained by reviewing their clinical records. Results: Ninety-six patients with SLE were studied. The female- to-male ratio was 12.7:1. Average age at diagnosis was 30.4 (SD ± 13.3) years. Ocular involvement was present in 36.4% (CI 95%=27.5-46.4) of patients. The most common ocular manifestation was keratoconjuntivitis sicca secondary to Sjögren's syndrome in 28.1% (CI 95%=20-37.8). Other manifestations were: scleritis, peripheral ulcerative keratitis, optic neuropathy, peripheral nerve paralysis, retinal vasculitis, central retinal vein occlusion, and central serous chorioretinopathy. Therapeutic complications included: chloroquine toxicity, seen in 10.4%, cataract formation in 9.3%, and cornea verticillata in 5.2% of the patients. Conclusions: Because nearly one third of patients with SLE experience ocular involvement, these patients should have periodical ophthalmologic evaluations for early detection of ocular manifestations and early detection of therapeutic complications. ©2012 Sociedad Mexicana de Oftalmología.

Publication date

  • October 1, 2012