Purpose: To determine the most frequent ocular manifestations in patients with epidermolysis bullosa in Mexico, and compare them with other published studies. Design: Observational cross-sectional. Methods: 23 Mexican patients from Instituto DEBRA México A.C. with diagnosis of recessive dystrophic epidermolysis bullosa underwent a complete ophthalmologic examination. The results were compared with the ones reported in the literature, using squared-chi(X2). Results: The study included 16 females (69.6%), and 7 males (30.4%) patients. With a mean age of 17.1 years (range 1-59 years). The 52.1% of the patients were found asymptomatic. The most frequent symptoms were: ocular irritation 30.4%, tearing 13.0% and palpebral bullae 8.6%. At the ophthalmic examination we found: blepharitis in 60.8%, meibomian gland dysfunction in 43.4%, symptomatic refractive errors in 39.1%, corneal scarring in 39.1%, and epithelial keratitis in 26.0%. Conclusions: The Recessive dystrophic epidermolysis bullosa is a rare genodermatosis, with formation of spontaneous bullae and ulcers that produce scarring. Patients must have a multidisciplinary treatment, with special attention to the external ocular surface to prevent scarring that can impair vision.