Efficacy of topical ganciclovir as therapeutic alternative in epithelial herpetic keratitis. Randomized clinical trial Eficacia del ganciclovir tópico como alternativa terapéutica de la queratitis epitelial herpética Academic Article in Scopus uri icon


  • © 2013 Sociedad Mexicana de Oftalmología.Objective: To compare the healing rate in less than 7 days with the use of ganciclovir or acyclovir in patients with epithelial herpetic keratitis. Materials and methods: We designed a randomized clinical trial including patients with epithelial herpetic keratitis seen at Centro de Oftalmología de la Fundación Santos y de la Garza Evia. There were 2 treatment groups: 0.15% ganciclovir gel and acyclovir 3% ointment, applied 5 times a day until the dendrite closed, and then 3 times a day for 3 days. We evaluated patients daily until the ulcer healed. A validated symptom scale was provided in each visit. Results: We recruited 23 patients: 13 treated with ganciclovir (56.5%) and 10 (43.4%) with acyclovir (P =.94), the mean age was 47.69 years (SD ± 18.6) for the first group, and 56.8 years (SD ± 9.6) for the second (P =.17). The initial ulcer size was similar in both groups: 2.3 mm (± 1.85) in acyclovir and 3.0 mm (± 0.94) in ganciclovir. On the first day the median ulcer size was 1.5 mm acyclovir (IQR = 1.8) and ganciclovir 1 mm (IQR = 1.9) (P = 0.257), which does not show a clinically significant difference. At day 7, the ulcer had closed to 0 mm (IQR = 0) in all cases of ganciclovir compared with acyclovir 1 mm (IQR = 1.7) (P =.000). Conclusions: The healing rate of ganciclovir in less than 7 days for EK was superior compared with acyclovir.

Publication date

  • January 1, 2014