The present paper attempts to shed light on the issues related to the war on drugs in Mexico, and their frequency of coverage in the international press. Agendasetting and domestication are two different approaches used to address them. The information was collected in one national and three international newspapers: The Guardian of England, The New York Times of the United States, El País of Spain, and El Universal of Mexico. A content analysis of news stories in the political transition period of the 2012 in the Mexican government was conducted. The results showed that while there is persistence in the number of news stories from the change of government, there is also a slight difference in the trend of themes that each of the newspapers reported.