abstract
- © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, WeinheimThe biofunctional significance of hollow mesoporous silica nanoparticles (HMSNs) could be used as nano-reservoirs. Here in the ß-sitosterol loaded into the hollow core and the cisplatin substituted with the carboxylic group of poly lactic acid (PLA)- polyethylene glycol (PEG) on the pore walls of HMSNs. Subsequently, the tumour biomarker somatostatin peptide (3207-86) conjugated to Methyl polyethylene glycol 2-maleimide ethyl ether (Meo-PEG-Mal) for the selective targeting of tumour cells. The surface modified HMSNs enable the internalization of cisplatin via chlorine ion release, through the cleavage of the coordinated interaction. Further, the ß sitosterol release is dependent on the discharge rate of cisplatin and the pH of the cell microenvironment. The engineered nano-drug delivery system could be used to selectively target cancer cells and deliver multimodal therapeutic schemes for the treatment of colon cancer.