Mortar cubes containing different addition levels (0, 1.5, 4, 8, 42, and 95%, by water mass replacement concentration) of Opuntia ficus-indica (OFI) mucilage were exposed for a 14-year (5110-day) period in a natural CO2-laden environment. Physical characterization tests were performed on the mortar cubes, such as saturated electrical resistivity (¿S), percent total void content (%TV), water capillary absorption (¿EFF), and compressive strength (fc). Changes in pH due to carbonation were also determined, and carbonation rates (KCO2) were recorded. Findings suggest that the addition of OFI mucilage concentrations between 4 and 8% (by water mass replacement) may be suitable for durability-enhancing applications in cement-based mortar exposed to carbonation-induced environments.