abstract
- Objective: To assess the association between serum level of progesterone during stimulation and in the luteal phase with pregnancy rate in a cohort of patients undergoing in vitro fertilization and embryo transfer (IVFET) on day 5. Methods: Retrospective Cohort Study. Patients: 62 infertile women, aged 24-42 years, undergoing ART at our center from May 2019 to May 2021. Progesterone was evaluated during ovarian stimulation on Day 2, Day 6, and Day 8 of stimulation, day of trigger (P4dhCG), and on the day of blastocyst transfer with 5 days of progesterone supplementation (P4d5+). We also calculated the difference of P4d5+ with P4dhCG. (¿P4). Then we divided the patients into two groups based on progesterone serum levels at P4d5+; <10ng/ml (Group A), ¿10ng/ml (Group B). The Student¿s t-test was performed for continuous variables; Mann-Whitney¿s Test and Spearman¿s Test were used where appropriate for categorical variables. p<0.05 was considered statistically significant. Results: There were positive correlations between ßhCG positive with P4d5+ (p<0.001; Rho 0.770) and ¿P4 (p<0.001; Rho 0.703). The pregnancy rate doubled when the serum progesterone level was ¿10ng/ml on the fifth day of progesterone supplementation compared with P4<10ng/ml (44% vs. 21%, respectively). Conclusions: The pregnancy rate was positively correlated with the serum P4 level on the fifth day of progesterone supplementation and with the difference between the serum progesterone level in the Dd5+ / dhCG. A higher pregnancy rate was observed when serum progesterone level on the fifth day of progesterone supplementation was ¿10ng/ml.