Development of an electrochemical sensor for the quantification of ascorbic acid and acetaminophen in pharmaceutical samples Academic Article in Scopus uri icon

abstract

  • This work presents the modification of glassy carbon electrodes (GCE) by using a dispersion resulting from the non-covalent functionalization of multi-walled carbon nanotubes (MWCNT) with polyarginine (polyArg). MWCNT-polyArg is used for the quantification of ascorbic acid (AA) in the presence of acetaminophen (APAP) and viceversa. Since ascorbic acid and acetaminophen are strongly absorbed on GCE/MWCNT-polyArg, they can be detected in the presence of 4.0×10¿5 M acetaminophen (and 3.0×10¿5 M ascorbic acid) by using adsorptive stripping with media exchange and differential pulse voltammetry. Using water as the solvent for the MWCNT dispersion, the result was Z-potential of 0.053 ± 0.006 V. The developed sensor showed excellent specificity, sensitivity, stability and reproducibility compared to previously published sensors. The GCE/MWCNT-polyArg sensor shows a fast response time of ~5 minutes, low limits of detection and quantification for AA (0.95 and 2.9 ¿M respectively) and APAP (0.27 and 0.82¿M, respectively), high sensitivity of 0.0616 ¿A/M for AA or APAP 0.240¿A/M. It was used to test its practicability by determining the concentration of AA or APAP (AA and APAP) in pharmaceutical samples. Finally, the simultaneous measurement of ascorbic acid and acetaminophen in pharmaceuticals showed a good correlation, with a maximum error and RSD of 4.5 and 5.1 %, respectively. © 2024 Elsevier B.V.

publication date

  • October 15, 2024