Small interfering RNA and aptamer-mediated nanomedicines for wound healing

Nanomedicine has emerged during the last decade as a promising option in the field of wound healing due to its potential for targeted and controlled delivery of therapeutic agents. This chapter analyzes current advances in the design, production, and efficacy of small interfering RNA (siRNA) and aptamer-mediated nanomedicine for wound healing applications. siRNA, known for its ability to silence specific genes, has been shown as therapeutic strategy that can modulate key molecular pathways involved in wound healing, such as inflammation, angiogenesis, and tissue regeneration. Moreover, aptamers, single-stranded oligonucleotides with high affinity and specificity for their targets, have garnered attention for their versatile applications in wound healing. We discuss the challenges and opportunities in translating these innovative approaches from preclinical studies to clinical applications. The integration of siRNA and aptamer-mediated nanomedicines may develop alternative new generation wound healing therapeutics with advantages and fewer side effects. © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.