The main field of nanomedicine is treating and diagnosing diseases through the improvement and use of nanotechnology and nanomaterials. Nanomaterial dimensions are between 1 and 100 nm, which is an appropriate size range for helping drags overcome biological barriers and contact the target. Nanoparticles (NPs) can also be designed to respond to endogenous or exogenous stimuli, such as enzymes, pH, glutathione or light, temperature, ultrasound, among others. The administration of drugs or therapeutic agents to the desired location is one of the main difficulties for achieving an efficient treatment in several diseases. The therapy with these agents has several shortcomings, such as reduced biodistribution, non-selectivity, low bioavailability, unwanted adverse effects, poor specificity, and low effectiveness. Polymers susceptible to temperature become totally miscible with water/solvent above or below the upper critical solution temperature or lower critical solution temperature, respectively.
