Fundamentals of drug delivery systems and application of MALDI-ToF-MS in drug delivery
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© The Author(s) 2017. Current chapter contains fundamentals of drug delivery systems and different means for transferring drugs to the targeted organs. This chapter explains the synthesis of poly caprolactone triol-co-citric acid (PCLT-CA) in different compositions and subsequent processing of the polymerized materials into the elastomeric films and coatings for drug delivery applications. A detailed MALDI-ToF-MS analysis was performed on different compositions of PCLT-CA as well as PCLT as a control. Confirmation of a progressive pre-polymerization was obtained by the help of MALDI analysis. In the current chapter, formation of the branched molecules of this polymer system, end-group analysis and structural analysis of the compositions are explained in a great detail. Moreover, application of developed materials in the field of drug delivery is discussed in regards to the chemical and mechanical properties of the synthesized copolymer compositions. Key aspects in biomaterials study such as degradation rate and kinetic of the drug release were chosen as the major focus areas in this chapter. Current chapter is dedicated to the MALDI analysis of a branched copolymer system with 2 monomers involved in synthesis reaction.