abstract
- © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021.Electrochemiluminescence (ECL) combines electrochemistry and chemiluminescence (CL) to offer a powerful technique for the detection of various analytes. The CL reaction is triggered and controlled by application of an electrochemical potential by which the generated species undergo electron-transfer reactions by moving form an excited to the original state of energy. This detection method (ECL) offers great advantages including better control over the light emission time, simultaneous acquisition of the current signal, and light compatibility with different phases of matter. Combination of this detection technique with bio-microelectromechanical systems (BioMEMS) contribute to the development of compact, sensitive, cost-effective, and portable systems that, in turn, may need small sample volumes for their operation. This chapter provides a thorough review of the latest advancements of BioMEMS that operate based on the principle of ECL detection. A detailed comparison between the fabrication and operation of these devices along with the advantages and disadvantages of each technique are also included in this chapter.