Bio-microelectromechanical systems (bioMEMS) in bio-sensing applications-colorimetric detection strategies

Colorimetric detection is one of the main strategies used in biosensors due to the inexpensive, rapid, and easy readout. Among the main types of colorimetric biosensors are paper-based, lab-on-chip, lab-on-compact disk, and other alternative devices. In this chapter, some of the recent examples of BioMEMS are provided including DNA-detecting sensors based on acpcPNA-induces NP aggregation, neuropeptide Y-detecting ELISA platforms, streptococcus pneumonia and E. coli-detecting biosensors incorporating nucleus acid extraction, smartphone-based devices for biomarkers detection in sweat and saliva, and glass nanofiber-based biosensors for the detection of cholinesterase inhibitors. This chapter provides a thorough review of the latest advancements in of bio-microelectromechanical systems (BioMEMS) that operate based on the principle of colorimetric detection. A detailed comparison between the fabrication and operation of these devices along with the advantages and disadvantages of each technique are also included in this chapter. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021.