abstract
- © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021.The light emission produced by living organisms is known as bioluminescence (BL), where a conversion of chemical energy into light energy occurs via a chemical-physical transduction. Contrasting fluorescence, BL measurements do not involve instant radiation, and the signal glows against dark backgrounds offering great sensitivity. Since BL can achieve non-invasive imaging in live animals, it has attracted considerable attention in various areas of research. The advantages of integrating BL detection strategies into bio-microelectromechanical systems (BioMEMS) involve reduced sample size, rapid detection, compact devices, and portable on-site analysis which eliminates the necessity for skilled operators and trained personnel. This chapter provides a thorough review on the latest advancements of BioMEMS that operate based on the principle of BL detection. A detailed comparison between the fabrication and operation of these devices along with the advantages and disadvantages of each technique are also included in this chapter.