Study of the chloroformic extract of Gnaphalium sp in a model of alloxaninduced diabetes in Wistar rats. An alternative use of the ¿gordolobo¿ plant within traditional Mexican medicine Estudio del extracto clorofórmico de Gnaphalium sp en un modelo de diabetes inducida por aloxana en ratas Wistar. Una alternativa del uso de la planta ¿gordolobo¿ dentro de la medicina tradicional mexicana Academic Article in Scopus uri icon

abstract

  • ¿Gordolobo¿ (Gnaphalium sp) is a Mexican medicinal plant understudied for the treatment of diabetes; therefore, the aim was to evaluate the chloroformic extract of G sp. (CEG) in alloxan-induced diabetic rats. Sesquiterpene lactones, polyphenolic compounds, triterpenes and steroids, apigenin, and lauric and myristic acid were identified in CEG by phytochemical, HPLC and GC-MS analysis; and the antioxidant capacity evaluated by FRAP, DPPH and ABTS, inhibited the formation of free radicals. There was no lethality or toxicity at doses of 2000 mg/kg. At doses of 200 mg/kg it did not decrease hyperglycemia; however, it did decrease biomarkers of oxidative stress (malondialdehyde, oxidized proteins, superoxide dismutase) associated with diabetes in pancreas. The ß-cell function, insulin resistance and insulin sensitivity were not improved. In conclusion, CEG showed no hypoglycemic activity, but antioxidant activity in pancreatic tissue. © 2025, MS-Editions. All rights reserved.

publication date

  • January 1, 2025