Obstetric and fetal-neonatal complications associated with dengue virus infection Academic Article in Scopus uri icon

abstract

  • Dengue is an acute febrile illness caused by the dengue virus, a member of the Flaviviridae family, and is widely distributed in tropical regions. Its clinical significance has increased due to the rising incidence of severe cases in hyper-endemic areas, particularly among younger populations, often attributed to exaggerated immune responses during secondary infections. The disease spectrum ranges from self-limited febrile illness to severe manifestations, including hemorrhagic complications and hypovolemic shock. During pregnancy, dengue is of particular concern, as infection¿especially in the third trimester¿is associated with increased risks of maternal mortality, obstetric complications, and adverse fetal and neonatal complications. Diagnosis is primarily based on clinical presentation, supported by serological testing to detect dengue-specific antigens and antibodies. Disease progression is monitored using laboratory parameters, including hematological indices and markers of hepatic dysfunction. No specific antiviral therapy exists for dengue; management remains supportive, with adequate hydration as the cornerstone of treatment. In pregnant patients, cautious clinical management is essential to mitigate complications and optimize maternal and fetal outcomes.

publication date

  • January 1, 2026