Disruptive ideas and innovative business models take shape from observing and investigating the needs and demands of potential users and measuring their success based on the acceptance by users and their satisfaction. In an educational context, a new mission of the university has emerged, supported by the transfer of open access knowledge through Institutional Repositories (IR); it is important to know the motivations and needs of the academic community to promote scientific dissemination using these platforms. The present article uses the method of systematic literature review: Using 29 studies from SCOPUS and WoS, involving the topics User-Centered Design (UCD) and repositories. The results show that two of the three UCD phases-evaluation and requirements-are closely linked and are the reiterative focus of UCD; thus, it is desirable to promote the design of custommade prototypes according to the users' motivations. It is necessary to redefine methodologies for IR development within open-access ecosystems to guide them towards meeting their potential users' needs and motivations. 2018, IGI Global.