Active pneumatic microballoon mixing on centrifugal microfluidic platforms

© 17CBMS-0001.In this study, we are introducing an liquid reciprocation technique on centrifugal microfluidic platforms based on active microballoons. The liquid reciprocation technique is tested for mixing 22 µl water with 3 µl color in a large-surface-area-to-volume-ratio chamber. The color homogenization within the shallow chamber was achieved in less than 5 seconds, during which about sixty liquid reciprocation cycles were accomplished. As an early proof of concept for using the active flow reciprocation mechanism and peptide microarrays in point of care (POC) diagnostics applications, we co-integrated both technologies in a microfluidic disc for detection of 15 nM anti-FLAG Cy5 antibodies.

Active pneumatic microballoon mixing on centrifugal microfluidic platforms Academic Article in Scopus