abstract
- © 2020 Elsevier Ltd. All rights reserved.Aligned nanostructures possess a great importance in biomedical applications due to their ability to promote cell attachment, proliferation and migration in vitro. Polymeric nanofibers are among the most popular options because of their ease of fabrication by various electrospinning techniques. The microstructure and alignment of the electrospun nanofibers is controlled by altering the fabrication variables and collector mechanisms. This manuscript details the various technologies currently being employed to control the alignment of electrospun nanofiber. Role of polymer related parameters including the electrospinning voltage and nanofiber collector are also detailed. Aligned nanofibers provides several unique advantages in the area of biomedical and tissue engineering. Application of these aligned nanostructures as bioactive materials for controlling cell behaviour, wound dressing material, drug delivery, cancer therapeutics and biosensing are outlined.