The mechanical reliability of vat photopolymerization 3D printing of isosorbide-derived polyester porous tissue engineering scaffolds Academic Article in Scopus uri icon

abstract

  • © 2022 The Authors. Published by Elsevier B.V.Photo-crosslinkable polymers are being studied as a potential 3D printable solution to the well-established need for biocompatible, highly elastic, and resorbable materials. Among the emerging materials that meet this need is a sugar-based polymer, an isosorbide-derived polyester, which represents a candidate for use in tissue engineered medical devices. Isosorbide polyesters are known to exhibit time-certain resorption profiles, offering not just biocompatibility and biodegradability, but can also be 3D printed by photocrosslinking. The 3D printing of medical devices requires accuracy, minimally, in the 10's of microns range. Preliminary data showing isosorbide-derived polyester 3D printing of scaffolds with an internal porosity is reported here. The pore geometry we used is Schoen's gyroid. Using an EnvisionTEC 3D printer (Dearborn, MI) we designed cylinders with 81% porosity using the gyroid pore geometry with a pore size of 800 µm and a strut size of 1000 µm.

publication date

  • January 1, 2022