CONTROLLED GENERATION OF CORE-SHELL GELMA MICROGEL USING A MULTI-LAYER DROPLET-BASED MICROFLUIDIC DEVICE Academic Article in Scopus uri icon

abstract

  • © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.This article presents the fabrication of monodisperse gelatin methacrylate (GelMA) core-shell microgels with high-resolution tunability and control using a newly designed, low-cost, multi-layer 3D droplet-based microfluidic device (DBMD). Using numerical analysis, the DBMD design was optimized for sufficient microgel crosslinking. Results revealed that the core and shell sizes could be controlled with high precision by adjusting the flow rates, i.e., the higher core and shell flow rates, the greater the core diameter and the shell thickness. A higher continuous flow rate generates smaller microgels. Successful encapsulation of microbeads (5-10 µm) was also conducted.

publication date

  • January 1, 2021