Green nanotechnology in cardiovascular tissue engineering Book in Scopus uri icon

abstract

  • © 2022 Elsevier Inc.Cardiovascular tissue engineering has been quickly escalating into one of the fastest-growing subsects within the field. This is due to the increase and prevalence of associated diseases and the need for tissue replacement and reconstruction. As one of the most novel additions to the cardiovascular platform, nanotechnology and nanomedicine-based approaches have been implemented over the last few years, including, but not limited to nanosurface modifications, combination with nanostructures, or the crosslinking of nanomaterials into cardiac patches and grafts, to improve cell adhesion, direct cell differentiation, and improve or alter the mechanical and electrical properties of the scaffolds. However, some of these nanoscale-based technologies present drawbacks related to their synthesis or subsequent implementation, such as the production of toxic by-products or the lack of biocompatibility, which induce toxicity and elicit immune responses beyond the desired thresholds. To overcome such limitations, green nanotechnology-based approaches appear in a sustainable, cost-effective, and environmentally friendly manner to create nanomaterials and nanofeatures with similar characteristics and properties to those produced by traditional means, but lacking the associated disadvantages. As such, this book chapter recovers and explains the most recent advances of these platforms, from the use of microbially derived strategies to the use of plants and animal tissues to build decellularized scaffolds. This chapter also covers usage of various biomolecules of interest, such as proteins, lipids, or amino acid, which show several improvements when implemented for the production of nanoscale platforms for cardiovascular tissue engineering.

publication date

  • January 1, 2022