abstract
- © 2021 Elsevier Inc. All rights reserved.Pharmacokinetic properties such as low water solubility and low bioavailability have limited the therapeutic applications of a vast number of natural compounds, which have shown potential when studied in vitro. In consequence, novel strategies have been developed to overcome these limitations. One of these approaches relies on the use of nanotechnology, providing alternative formulations by encapsulating the compounds of interest, which by modulating their size and charge, among other physicochemical characteristics, these tailor-made nanoconstructs may enhance and take advantage of the benefits of natural compounds. In this chapter, the concept of nanotechnology will be introduced, followed by techniques employed for cardiac tissue and mitochondrial targeting, finally presenting a review of the work done in which nanotechnology for encapsulating and delivering natural compounds for the treatment of cardiovascular diseases.