Chronic skin wounds represent an important challenge that can benefit from the development of advanced delivery systems based on plant-derived bioactive compounds. This study evaluates the feasibility of fabricating hybrid textile scaffolds by combining electrospinning (ESP), melt electrowriting (MEW), and fused deposition modeling (FDM) to incorporate bioactives obtained from Opuntia ficus-indica (prickly pear cactus) flour for potential wound care applications. MEW was used to produce microfibrous textiles with controlled architecture and pore size, allowing modulation of structural and mechanical properties. Electrospinning enabled the incorporation of Opuntia ficus-indica bioactive compounds, rich in polysaccharides and flavonoids, within polymeric fibers designed for localized and sustained release. To improve handling, stability, and fixation of the textile constructs, FDM was employed to integrate reinforcing fibers with larger diameters. The manufacturing process was optimized by adjusting polymer type, polymer-to-flour ratio, and precursor solution preparation to obtain homogeneous scaffolds with reproducible properties. The resulting hybrid textiles combine structural support, high surface area, and bioactive delivery capacity within a single construct. The novelty of this work lies in the integration of three additive manufacturing techniques with a sustainable, plant-based bioactive material, offering a versatile and scalable platform for the development of functional wound dressings. This approach highlights the potential of Opuntia ficus-indica as a value-added horticultural resource and supports its application in bio-based materials for health-related uses.
