Transferosomes as a delivery system for bioselenized protein hydrolysates as an active ingredient with cosmetic activity Academic Article in Scopus uri icon

abstract

  • In higher education, research-based learning could be a valuable addition to the curriculum as a didactic-pedagogical strategy, as it allows students to observe, analyze, reflect, and solve problems. In the context of engineering education, it would be beneficial for students to have the opportunity to apply their learning in a real-world setting during their professional training. It would seem that students in their final semester of nanotechnology engineering have found a way to apply this learning technique in the Integration Project in Chemistry and Nanotechnology. The project developed by the students is about transferomonas with a real application in the dermatological industry. Transferosomes are flexible vesicular carriers capable of deforming up to 10 times their size. They are used to enhance the stability, permeability, and biological activity of the encapsulated active ingredients. In this research, transferosomes were employed to encapsulate bioselenized protein hydrolysates to increase their stability and topical permeability when used in cosmetic formulations to combat signs of aging. The encapsulation efficiency achieved was 70%, while the release assays indicated that 38% of the active ingredient was released after 4 hours of contact with the skin's pH. These results demonstrate the successful optimization of conditions for the formation of transferosomes with bioselenized protein hydrolysates as the active ingredient, as well as their potential use in the cosmetic industry. Future investigations should focus on studying the permeability of transferosomes, considering the dermis as their ultimate destination. The research-based learning technique proved to be an effective approach for solving problems in higher education students. © 2024 Latin American and Caribbean Consortium of Engineering Institutions. All rights reserved.

publication date

  • January 1, 2024