Phenolic compounds are bioactive molecules widely distributed in plants. However, limited solubility and their low stability under light, pH, and environmental conditions affect their chemical stability and decrease their absorption efficiency. Recently, nanotechnology has provided an alternative to overcome these challenges, increasing the stability and therefore the biological activity of the phenolic compounds. This review will focus on the main nanoformulations used to encapsulate phenolic compounds and the effect of loading these compounds on their biological activity. Different nanoformulations systems such as lipids-based, protein-based, and polymeric-based have been used for loading polyphenols. Phenolic compounds¿ incorporation into these nanoformulations has shown an increase in their storage and processing stability, an increase in bioaccessibility and bioavailability, and less side effects. Recent studies in this field have pointed out the design of specific solution-oriented nanocarriers as the goal and the design of targeting therapies based on phenolic compounds. Through nanotechnology, it¿s possible to develop novel delivery systems to incorporate labile bioactive molecules, such as phenolic compounds.
