Perspectives and Future Trends in Aqueous Two-Phase System-Based Technology Chapter in Scopus uri icon


  • © 2017, Springer International Publishing AG. Aqueous two-phase systems (ATPS) are regarded as an effective primary recovery and partial purification technique for biological products. However, although much has been developed through the last 50 years, there are still advances to address concerning the handling, improvement, and alternative uses of ATPS. Therefore, although ATPS has proven to be in most cases an effective strategy for the recovery and partial purification of biologicals and overcoming some of the disadvantages of conventional processing approaches (such as solid-phase extraction or liquid chromatography), their use has been primordially limited to lab scale due to the lack of an economic analysis supporting the benefits of their use at industrial level. In this final chapter, a brief overview of the trends and perspectives that are envisioned in the ATPS field for the next years is presented. These trends focused on areas such as ATPS enhancement, novel applications, and economic feasibility of large-scale implementation. Finally, general concluding remarks on ATPS technology are given.

publication date

  • January 1, 2017