Preparation of Gelatin/Polyvinyl alcohol decorated with WO3 for cartilage regeneration Academic Article in Scopus uri icon

abstract

  • Research-based learning offers a stimulating approach to understanding bone regeneration. Students can formulate research questions, such as optimizing biomaterial design for enhanced healing. This delves into the current body of knowledge on bone structure, growth factors, and biocompatible materials. A Student for eight semesters of Nanotechnology Engineering collaborating with a master's Nanotecnology student at Tec de Monterrey was selected to be trained and develop a theoretical and experimental frame on new alternatives in hydroxyapatite for bone regeneration. Ceramic particles have been widely used in developing new materials with biomedical applications. However, no material has been found that can match the properties of natural tissues and organs, so considering the evaluation of different ceramic particles for biological fines could help meet the current needs of the materials to be developed. Tungsten trioxide (WO3) is a peculiar ceramic particle since various investigations have shown that, in addition to its use in piezoelectric devices, it has anti-carcinogenic properties at low concentrations and promotes bioactivity on the surfaces of inert materials. In this document, WO3 nanoparticles have been synthesized by an acid precipitation method supported by a hydrothermal treatment. The obtained particles were used to evaluate their cytotoxicity using a cell viability test in cell lines belonging to fibroblasts and osteoblasts. The best concentration was 31 µg/ml. On the other hand, at the concentrations used, WO3 did not increase cell death. Instead, it promoted bioactivity, so it is presented as a material that could be used with biomedical applications. This fosters a profound understanding of bone biology, the complexities of regeneration, and the potential solutions researchers are exploring. © 2024 Latin American and Caribbean Consortium of Engineering Institutions. All rights reserved.

publication date

  • January 1, 2024