mario.alvarez@tec.mx
governing authority
- Biomedical Engineering Research Group
Campus
- Leader, Biomedical Engineering , School of Engineering and Sciences
- Campus Monterrey, School of Engineering and Sciences , Tecnológico de Monterrey
Alvarez,Mario Moisés
Overview
Profesor Insignia Rómulo Garza 2016; Investigador Nacional Nivel III (SIN III);Research Group Director
- Overview
- Publications
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Overview
Publications
selected publications
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academic article
- Anti-Ebola therapies based on monoclonal antibodies: Current state and challenges ahead 2015
- Identification of Potential Therapeutic Targets for Cancer Stem Cell-Specific Combined Therapy through Gene Expression Profiling using Tumorsphere-Enriched Cultures of Prostate Cancer Cell Lines 2015
- Attributes of potential entrepreneurs: An exploratory study on the perceptions of Latin American undergraduate students 2014
- Collaboration in Entrepreneurial Biodiversity: The Case of Mexico 2014
- Fine-tuning Entrepreneurship Education: how do Programs Impact Entrepreneurial characteristics in Students? 2014
- Understanding potential entrepreneurs 2014
- Measuring entrepreneurial competences 2014
- Perfil del Emprendedor: Un Estudio Comparativo entre Estudiantes de Países de Iberoamérica 2014
- The significance of the university environment for entrepreneurship education: A case study of an entrepreneurial university in Mexico 2014
- Mathematical Modeling of the Serum Concentration of Norelgestromin and Ethinylestradiol Released by a Contraceptive Patch. 2014
- Continuous monoclonal antibody production on a chip 2013
- Scaling down the production of biopharmaceuticals to continuous micro-chips 2013
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academic article in scopus
- Modeling COVID-19 epidemics in an Excel spreadsheet to enable first-hand accurate predictions of the pandemic evolution in urban areas. Scientific Reports. 11. 2021
- Advances in 3D bioprinting for the biofabrication of tumor models. Bioprinting. 21. 2021
- Continuous chaotic bioprinting of skeletal muscle-like constructs. Bioprinting. 21. 2021
- Colorimetric loop-mediated isothermal amplification (LAMP) for cost-effective and quantitative detection of SARS-CoV-2: The change in color in LAMP-based assays quantitatively correlates with viral copy number. Analytical Methods. 13:169-178. 2021
- Strategies for antimicrobial peptide coatings on medical devices: a review and regulatory science perspective. Critical Reviews in Biotechnology. 41:94-120. 2021
- Characterization of a novel automated microfiltration device for the efficient isolation and analysis of circulating tumor cells from clinical blood samples. Scientific Reports. 10. 2020
- Carbon-Nanogold Hierarchical Micro/Nano Topographies for Cell Guidance. Advanced Materials Interfaces. 7. 2020
- Characterization of chemically activated pyrolytic carbon black derived from waste tires as a candidate for nanomaterial precursor. Nanomaterials. 10:1-22. 2020
- Expanding sacrificially printed microfluidic channel-embedded paper devices for construction of volumetric tissue models in vitro. Biofabrication. 12. 2020
- Portable and accurate diagnostics for COVID-19: Combined use of the miniPCR thermocycler and a well-plate reader for SARS-CoV-2 virus detection. PLoS ONE. 15. 2020
- Using chaotic advection for facile high-throughput fabrication of ordered multilayer micro-and nanostructures: Continuous chaotic printing. Biofabrication. 12. 2020
- Nano-spaced Gold on Glassy Carbon Substrate for Controlling Cell Behavior. Advanced Materials Interfaces. 7. 2020
- High-Throughput Automated Microscopy of Circulating Tumor Cells. Scientific Reports. 9. 2019
- The tumor-on-chip: Recent advances in the development of microfluidic systems to recapitulate the physiology of solid tumors. Materials. 12. 2019
- Validation of use of the miniPCR thermocycler for Ebola and Zika virus detection. PLoS ONE. 14. 2019
- Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications. Biomaterials. 197:345-367. 2019
- Analysis of the knowledge landscape of three-dimensional bioprinting in Latin America. International Journal of Bioprinting. 5:16-25. 2019
- Chaotic printing: Using chaos to fabricate densely packed micro- and nanostructures at high resolution and speed. Materials Horizons. 5:813-822. 2018
- Men who have sex with men and human immunodeficiency virus testing in dental practice Hombres que tienen sexo con hombres y detección del virus de la inmunodeficiencia humana en odontología. Gaceta Sanitaria. 32:262-268. 2018
- Spatially and temporally controlled hydrogels for tissue engineering. Materials Science and Engineering: R: Reports. 119:1-35. 2017
- Bioprinted Osteogenic and Vasculogenic Patterns for Engineering 3D Bone Tissue. Advanced healthcare materials. 6. 2017
- Emerging Trends in Micro- and Nanoscale Technologies in Medicine: From Basic Discoveries to Translation. ACS Nano. 11:5195-5214. 2017
- Interplay between materials and microfluidics. Nature Reviews Materials. 2. 2017
- Evaluation of changes in promoters, use of UCOES and chain order to improve the antibody production in CHO cells. Protein Expression and Purification. 132:108-115. 2017
- Expansion mini-microscopy: An enabling alternative in point-of-care diagnostics. Current Opinion in Biomedical Engineering. 1:45-53. 2017
- Potential gingival crevicular fluid and serum biomarkers by stage of HIV infection. Cytokine. 91:96-103. 2017
- Anti-Ebola therapies based on monoclonal antibodies: current state and challenges ahead. Critical Reviews in Biotechnology. 37:53-68. 2017
- Rapid Continuous Multimaterial Extrusion Bioprinting. Advanced Materials. 29. 2017
- Delivery strategies to control inflammatory response: Modulating M1¿M2 polarization in tissue engineering applications. Journal of Controlled Release. 240:349-363. 2016
- Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells. Cytotechnology. 68:1287-1300. 2016
- Hybrid Microscopy: Enabling Inexpensive High-Performance Imaging through Combined Physical and Optical Magnifications. Scientific Reports. 6. 2016
- Strontium (Sr) and silver (Ag) loaded nanotubular structures with combined osteoinductive and antimicrobial activities. Acta Biomaterialia. 31:388-400. 2016
- Examining entrepreneurial attributes of Latin American female university students. Gender and Education. 28:148-166. 2016
- In vivo anti-inflammatory effects of isorhamnetin glycosides isolated from Opuntia ficus-indica (L.) Mill cladodes. Industrial Crops and Products. 76:803-808. 2015
- High loaded dendrimers with free peripheral groups. Tetrahedron Letters. 56:6803-6806. 2015
- Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels. Biomaterials. 73:254-271. 2015
- Amino acid consumption in naïve and recombinant CHO cell cultures: producers of a monoclonal antibody. Cytotechnology. 67:809-820. 2015
- Antibody derived peptides for detection of Ebola virus glycoprotein. PLoS ONE. 10. 2015
- Enrichment of the cancer stem phenotype in sphere cultures of prostate cancer cell lines occurs through activation of developmental pathways mediated by the transcriptional regulator ¿Np63¿. PLoS ONE. 10. 2015
- Supercritical CO2 foaming of thermoplastic materials derived from maize: Proof-of- concept use in mammalian cell culture applications. PLoS ONE. 10. 2015
- Molecular evolution and expression profile of the chemerine encoding gene RARRES2 in baboon and chimpanzee. Biological Research. 48. 2015
- Induction of Apoptosis in Colon Cancer Cells Treated with Isorhamnetin Glycosides from Opuntia Ficus-indica Pads. Plant Foods for Human Nutrition. 69:331-336. 2014
- Studying mixing in Non-Newtonian blue maize flour suspensions using color analysis. PLoS ONE. 9. 2014
- Continuous flow micro-bioreactors for the production of biopharmaceuticals: The effect of geometry, surface texture, and flow rate. Lab on a Chip - Miniaturisation for Chemistry and Biology. 14:1320-1329. 2014
- Mathematical modeling of the release of active ingredients from a contraceptive patch: Ortho Evra® as a case study. Iranian Journal of Pharmaceutical Research. 13:39-48. 2014
- Toxicity of flue gas components from cement plants in microalgae CO2 mitigation systems. Journal of Applied Phycology. 26:357-368. 2014
- A Colorful Mixing Experiment in a Stirred Tank Using Non-Newtonian Blue Maize Flour Suspensions. Journal of Chemical Education. 91:1729-1735. 2014
- Developing entrepreneurial competences in students in the life sciences: The Lifetech Ad-Venture program. On the Horizon. 22:182-191. 2014
- The simplest stirred tank for laminar mixing: Mixing in a vessel agitated by an off-centered angled disc. AICHE Journal. 59:3092-3108. 2013
- A baseline process for the production, recovery, and purification of bacterial influenza vaccine candidates. Biotechnology Progress. 29:896-908. 2013
- Microplates as a microreactor platform for microalgae research. Biotechnology Progress. 29:638-644. 2013
- A biopharmaceutical plant on a chip: Continuous micro-devices for the production of monoclonal antibodies. Lab on a Chip - Miniaturisation for Chemistry and Biology. 13:1243-1246. 2013
- A simple eccentric stirred tank mini-bioreactor: Mixing characterization and mammalian cell culture experiments. Biotechnology and Bioengineering. 110:1106-1118. 2013
- Application of eccentrically agitated stirred tanks in biotechnology settings: Examples, advantages, and challenges 2012
- Enhancement of cell adhesion and proliferation through surface roughness modification in CHO cell cultures in PMMA-PDMS micro-devices 2012
- Clinical and epidemiological features of 2009 pandemic H1N1 influenza differ slightly according to seroprevalence status during the second wave in the general population in México. Respiratory Care. 57:1586-1593. 2012
- State-of-the-art in downstream processing of monoclonal antibodies: Process trends in design and validation. Biotechnology Progress. 28:899-916. 2012
- A simple mathematical model based on the cancer stem cell hypothesis suggests kinetic commonalities in solid tumor growth. PLoS ONE. 7. 2012
- Effect of different agitation systems and protocols on the growth of Nicotiana tabacum cells: Comparison of growth kinetics in Erlenmeyer flasks, conventional stirred tanks, and eccentrically agitated tank bioreactors 2011
- Gene expression profiling of CD133 + prostate cancer stem cells induced from PC3 carcinoma cell line cultures 2011
- Seroprevalence of antibodies to influenza A/H1N1/2009 among transmission risk groups after the second wave in Mexico, by a virus-free ELISA method. International Journal of Infectious Diseases. 15. 2011
- Use of a plackett-burman statistical design to determine the effect of selected amino acids on monoclonal antibody production in CHO cells. Biotechnology Progress. 27:1709-1717. 2011
- Effect of different agitation systems and protocols on the growth of Nicotiana tabacum cells: Comparison of growth kinetics in erlenmeyer flasks, conventional stirred tanks, and eccentrically agitated tank bioreactors 2011
- Effect of different agitation systems and protocols on the growth of Vicotiana tabacum cells: Comparison of growth kinetics in erlenmeyer flasks, conventional stirred tanks, and eccentrically agitated tank bioreactors 2011
- Gene expression profiling of CD133+ prostate cancer stem cells induced from PC3 carcinoma cell line cultures 2011
- The receptor-binding domain of influenza virus hemagglutinin produced in Escherichia coli folds into its native, immunogenic structure. Journal of Virology. 85:865-872. 2011
- Kinetic analysis and mathematical modeling of growth and lactic acid production of Lactobacillus casei var. rhamnosus in milk whey. Journal of Dairy Science. 93:5552-5560. 2010
- Specific recognition of influenza A/H1N1/2009 antibodies in human serum: A simple virus-free ELISA method. PLoS ONE. 5. 2010
- An Influenza A/H1N1/2009 hemagglutinin vaccine produced in Escherichia coli. PLoS ONE. 5. 2010
- Compact cancer biomarkers discovery using a swarm intelligence feature selection algorithm. Computational Biology and Chemistry. 34:244-250. 2010
- Effect of decortication and protease treatment on the kinetics of liquefaction, saccharification, and ethanol production from sorghum. Journal of Chemical Technology and Biotechnology. 85:1122-1129. 2010
- Hydrodynamic conditions induce changes in secretion level and glycosylation patterns of Von Willebrand factor (vWF) in endothelial cells. Journal of Bioscience and Bioengineering. 109:400-406. 2010
- Production of probiotic biomass (Lactobacillus casei) in goat milk whey: Comparison of batch, continuous and fed-batch cultures. Bioresource Technology. 101:2837-2844. 2010
- Human hematopoietic progenitor cells grow faster under rotational laminar flows.. Biotechnology Progress. 26:1465-1473. 2010
- 96-well culture microplates as a microreactor platform for microalgae research 2009
- Culture of human cells in asymmetric laminar flow systems 2009
- Production of probiotic biomass (lactobacillus casei) in goat milk whey: Comparisson of batch, continuous and fedbatch cultures 2009
- Pseudo-chemical mathematical model for tumor growth based on the cancer stem cell hypothesis 2009
- The simplest stirred tank bioreactor 2009
- Viable and non viable microalgae fractionation employing insulator-based dielectrophoresis 2009
- Production of freeze dried protein and Lactobacillus casei probiotic biomass from goat milk whey Producción de proteína y biomasa probiótica de Lactobacillus casei liofilizadas a partir de suero de leche de cabra. Revista Mexicana de Ingeniera Quimica. 8:67-76. 2009
- A scalable 30 ml bioreactor for biopharmaceutical screening 2008
- Hydrodynamic conditions in a simple rotating microbioreactor induce changes in excretion level and glycosylation patterns of the Von Willebrand factor (vWF) in endotellial cells 2008
- Effect of sorghum decortication and use of protease before liquefaction with thermoresistant ¿-amylase on efficiency of bioethanol production. Cereal Chemistry. 85:792-798. 2008
- Effect of mixing during fermentation in yogurt manufacturing. Journal of Dairy Science. 91:4454-4465. 2008
- Novel bioreactor design for the culture of suspended mammalian cells. Part I: Mixing characterization. Chemical Engineering Science. 61:8075-8084. 2006
- Experimental visualization of mixing pathologies in laminar stirred tank bioreactors. Chemical Engineering Science. 60:2449-2457. 2005
- Comparison of histopathology, culture and PCR for diagnosis of bovine tuberculosis Comparación de histopatología, cultivo y PCR en el diagnóstico de tuberculosis bovina. Revista Cientifica de la Facultad de Ciencias Veterinarias de la Universidad del Zulia. 15:103-108. 2005
- Dry granular flows can generate surface features resembling those seen in Martian gullies. Proceedings of the National Academy of Sciences of the United States of America. 101:8542-8546. 2004
- Laminar mixing in eccentric stirred tank systems. Canadian Journal of Chemical Engineering. 80:546-557. 2002
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patent
- Iniciadores y Sondas para la amplificación y detección molecular de ARN del Virus de la Influenza tipo A H1N1 brote 2009 2017
- Proceso para la producción de L-Lactato mediante fermentación de lactosuero con lactococcus lactis subespecie lactis 2016
- Proceso para producción de L-lactato mediante fermentación de lactosuero con lactoccoccus lactis subespecie lactis 2016
- Proceso De Alto Rendimiento Para La Produccion De Biomasa Probiotica De Bacterias Lacticas A Partir De Suero De Leche No Suplementado 2015
- Sistema de agitación inducida por una plataforma de movimiento rotacional concéntrico para cultivo de células y tejidos. 2015
- 63. Inmunoensayo para determinar la cantidad de anticuerpos específicos contra Influenza A-H1N1 en muestras de suero sanguíneo. 2015
- Materiales termoplastificados derivados de proteínas de cápside viral recombinantes, su uso como vacunas de liberación prolongada, y su proceso de fabricación 2015
- USO DE ANTÍGENOS RECOMBINANTES DIMÉRICOS PRODUCIDOS EN Escherichia coli PARA DETERMINAR LA CANTIDAD DE ANTICUERPOS ESPECIFICOS CONTRA VIRUS DE INFLUENZA EN MUESTRAS DE SUERO SANGUÍNEO 2014
- "MICRO-REACTORES CONTINUOS DE CANAL PARA LA PRODUCCION DE BIOFARMACOS EN CELULAS DE OVARIO DE HAMSTER CHINO" 2014
- Micro-reactores continuos compartametalizados para la producción de biofarmacos en celulas de ovario de hamster chino 2014
- Dendrimeros y Dendrones Multifuncionales con alta capacidad de carga 2014
- Dispositivo electronico de iluminación controlada para el estudio de Microorganismos fotosintéticos y/o materiales fotosensibles o fotoresponsivos 2013
- Dispositivo electronico de iluminación controlada para el estudio de Microorganismos fotosintéticos y/o materiales fotosensibles o fotoresponsivos 2013
- Multifuncional dendrons and dendrimers with high loading capacity 2013
- Multifunctional dendrons and dendrimers with High loading capacity 2013
- Método para obtener en Pichia pastoris proteinas recombinantes con capacidad ADN polimerasa 2013
- Método para obtener proteínas recombinantes con capacidad inmunogenica en Pichia pastoris y su uso en una preparación de vacunas contra virus de influenza 2013
Research
Expertise ODS
other research activities
Teaching
teaching activities
- Advanced Topics in Bioprocesses
- Bioreaction and Bioreactors Engineering
- Bioreactors
- Doctoral Defense
- Doctoral Research
- Engineering Innovation Design Project
- Guided Research
- Integrated Exam
- Integration Project in Chemistry and Nanotechnology
- Methodologies for Innovation
- Pharmaceutical Bioengineering
- Product and Service Engineering
- Professional Experience Internship
- Research Internship
- Research Proposal
- Research Seminar
- Thesis
Background
education and training
- Biochemical engineer, Tecnológico de Monterrey
- Doctor of Philosophy, Rutgers The State University of New Jersey
- Master in Science, Rutgers The State University of New Jersey
- Master of Science with a specialty in Chemical Engineering, Tecnológico de Monterrey
awards and honors
Contact
full name
- Mario Moisés Alvarez