Publications in VIVO

Martínez-Calderón, Luz María

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BIOGRAPHY Dr. Luz María Martínez is a Research Professor of Tecnológico de Monterrey at the Department of Chemistry and Nanotechnology, in Monterrey, Mexico. She graduated with honors from Tecnológico de Monterrey with a Bachelor of Science in Chemistry. She received her Ph.D. in Chemistry from Arizona State University. During her Ph.D. at ASU she studied structural relaxation in the glass transformation range under the supervision of Dr. C. Austen Angell. Dr. Martinez has worked in the glass industry in the development of analytical techniques to measure and control physical and chemical properties of colored glasses. Her current research focuses on the preparation and characterization of novel co-amorphous drug binary systems with enhanced thermal stability and solubility. The main goal of her research group is the design of amorphous multicomponent pharmaceutical formulations with potential use in combination therapy to treat high incidence diseases such hypertension, diabetes and hypercholesterolemia. For her educational and scientific projects she has received several awards: - National recognition as Inspiring Professor. - Distinguished Novus-Professor (distinction for profile as an innovator in education). - MUJER-TEC-2013 (mentoring category). - First Place award of Scientific Integration in Technology Development. RESEARCH ----- Novel co-amorphous drug binary systems; Enhancement of thermal stability, solubility and bioavailability. ----- Thermal characterization of active ingredients and biomolecules with applications in the biotechnology and pharmaceutical industry ----- Design and construction of portable instruments of Differential Thermal Analysis (DTA) for thermal characterization of materials Recent representative publications Jorge Cruz-Angeles, Marcelo Videa and Luz María Martínez "Highly Soluble Glimepiride and Irbesartan Co-amorphous Formulation with Potential Application in Combination Therapy" (AAPS PharmSciTech 20:144, 1-12 (2019) DOI: 10.1208/s12249-019-1359-2 L.M. Martínez and M. Videa "Different Approaches to Teach Thermal Analysis; Roles of Undergraduate Students: Trainee, Tutor and Designer" Int J Interact Des Manuf 1-11(2019). ISSN1955-2505 Paula Eugenia Morales, Jorge Cruz, Cecilia Martínez, Marcelo Videa, Luz María Martínez "Nano and micro dispersions of two-phase amorphous-amorphous drug formulations as strategy to enhance solubility of pharmaceuticals" Materials Today proceedings 13 (2019) 390-396 Cecilia Martínez-Jiménez, Jorge Cruz-Angeles, Marcelo Videa and Luz María Martínez "Co-Amorphous Simvastatin-Nifedipine with Enhanced Solubility for Possible Use in Combination Therapy of Hypertension and Hypercholesterolemia" Molecules, 23, 2161 (2018); doi:10.3390/molecules23092161 L. M. Martínez, M. Videa, T. López, S. Castro, A. Caballero, V. Lara, and F. Castorena "Two-phase amorphous-amorphous solid drug dispersion with enhanced stability, solubility and bioavailability; resulting from ultrasonic dispersion of an immiscible system" European Journal of Pharmaceutics and Biopharmaceutics, 119 243-252 (2017) L. M. Martínez, M. Videa , Nahida Gonzalez. Héctor Ramirez, Samuel Castro" Long term stability of new co-amorphous drug binary systems: Study of glass transitions as a function of composition and shelf time" Molecules 21 (1712),1-13 ( 2016) doi: 10.3390/molecules21121712 Martínez Luz María, Videa Marcelo, Jorge Cruz-Angelez, Sara L. Rodríguez "Controlled water content for evaluation of denaturation temperature of freeze-dried enzymes" Thermochimica Acta 638 (2016) 52¿57.

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