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Chapoy-Villanueva, Héctor

Overview

In the development of my short career in scientific research, my learning and training has focused on studying the participation of various genes in the development of cancer and heart disease. During my doctoral training I designed and evaluated the efficiency of a neutral liposomal system for the delivery of siRNA in murine models of cervical and lung cancer. In this time, I learned important tools in the area of gene therapy and nano-vectors. After obtaining my doctoral degree, I became a postdoctoral fellow in the Laboratory of Cardiovascular and Metabolomic Medicine (Tecnologico de Monterrey), studying the regulation of genes involved in the development of cardiovascular diseases as heart failure (HF). In particular, I focused on elucidating the role of the mitochondrial calcium uniporter (mtCU) in cardiac pathology. The behavior of this channel and its subunits are fundamental for the handling of intramitochondrial calcium, a key element in many vital processes including ATP production and cell death. I led a study showing that hypothyroidism can modulate the stoichiometry of the mtCU components MICU1 and MCU, leading to cardioprotection against ischemia-reperfusion injury. We were able to attribute this cardioprotection to decreased sensitivity to mitochondrial permeability transition pore (mPTP) opening. I have also studied the role of the mPTP in cardiotoxicity in multiple collaborative studies. My goals in continuing my postdoctoral training to further explore the relationship between mtCU dysregulation, mitochondrial calcium overload, and mPTP opening in the development of cardiovascular diseases such as heart failure.
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