Martínez-Ledesma, Juan Emmanuel

academic article in scopus

• Neuronal differentiation drives the antitumor activity of mitogen-activated protein kinase kinase (MEK) inhibition in glioblastoma.  Neuro-Oncology Advances.  2023
• Epigenetics of neural differentiation: Spotlight on enhancers.  Frontiers in Cell and Developmental Biology.  10. 2022
• Dna repair genes as drug candidates for early breast cancer onset in latin america: A systematic review.  International Journal of Molecular Sciences.  22. 2021
• Intrinsic interferon signaling regulates the cell death and mesenchymal phenotype of glioblastoma stem cells.  Cancers.  13. 2021
• Robust Discovery of Mild Cognitive Impairment Subtypes and Their Risk of Alzheimer's Disease Conversion Using Unsupervised Machine Learning and Gaussian Mixture Modeling.  Current Alzheimer Research.  18:595-606. 2021
• Bowel obstruction as a serious complication of patients with femoral hernia.  Surgery Today.  51:738-744. 2021
• Detection of carbapenems resistant k-mer sequences in bacteria of critical priority by the world health organization (pseudomonas aeruginosa and acinetobacter baumannii) 2020
• EGFR amplification induces increased DNA damage response and renders selective sensitivity to talazoparib (PARP inhibitor) in glioblastoma.  Clinical Cancer Research.  26:1395-1407. 2020
• Comparative Molecular Life History of Spontaneous Canine and Human Gliomas.  Cancer Cell.  37:243-257.e7. 2020
• Computational methods for detecting cancer hotspots.  Computational and Structural Biotechnology Journal.  18:3567-3576. 2020
• Landscape of germline mutations in dna repair genes for breast cancer in latin america: Opportunities for parp-like inhibitors and immunotherapy.  Genes.  10. 2019
• TIE2¿FGFR1 interaction induces adaptive PI3K inhibitor resistance by upregulating Aurora A/PlK1/CDK1 signaling in glioblastoma.  Cancer Research.  79:5088-5101. 2019
• Identification of outcome-related driver mutations in cancer using conditional co-occurrence distributions.  Scientific Reports.  7. 2017
• Efficient gene selection for cancer prognostic biomarkers using swarm optimization and survival analysis.  Current Bioinformatics.  11:310-323. 2016
• Integration and comparison of different genomic data for outcome prediction in cancer.  BioData Mining.  8. 2015
• Identification of a multi-cancer gene expression biomarker for cancer clinical outcomes using a network-based algorithm.  Scientific Reports.  5. 2015
• Comparison of gene expression patterns across 12 tumor types identifies a cancer supercluster characterized by TP53 mutations and cell cycle defects.  Oncogene.  34:2732-2740. 2015